Mark Zuckerberg & Dr. Priscilla Chan

Sponsors: Eight Sleep & LMNT; The Brain Body Contract

Chan Zuckerberg Initiative (CZI) & Human Disease Research

Innovation & Discovery, Science & Engineering

Funding, Building Tools & Imaging

Healthy vs. Diseased Cells, Human Cell Atlas & AI, Virtual Cells

Single Cell Methods & Disease; CELLxGENE Tool

Sponsor: AG1

AI & Hypothesis Generation; Long-term Projects & Collaboration

Large Language Models (LLMs), In Silico Experiments

CZI Biohubs, Chicago, New York

Universities & Biohubs; Therapeutics & Rare Diseases

Optimism; Children & Families

Sponsor: InsideTracker

Technology & Health, Positive & Negative Interactions

Algorithms, Clickbait News, Individual Experience

Parental Controls, Meta Social Media Tools & Tailoring Experience

Time, Usage & Technology, Parental Tools

Virtual Reality (VR), Mixed Reality Experiences & Smart Glasses

Physical Exercise & Virtual Product Development

Virtual Futures for Creativity & Social Interactions

Ray-Ban Meta Smart Glasses: Potential, Privacy & Risks

Visual System & Smart Glasses, Augmented Reality

AI Assistants & Creators, Identity Protection

Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter

- The Huberman Lab Podcast features Andrew Huberman, a professor at Stanford School of Medicine.
- The podcast includes interviews with Mark Zuckerberg and Dr. Priscilla Chan, discussing the Chan Zuckerberg Initiative (CZI).
- CZI aims to cure all human diseases through funding, cell research, and AI platforms.
- CZI's goals include understanding disease processes and developing tools for scientific research.
- CZI funds science, builds software and hardware, and collaborates with scientists to create durable tools.
- Sponsors Eight Sleep and Element are mentioned, offering smart mattress covers and electrolyte drinks respectively.
- Upcoming live events in Australia focused on mental health, physical health, and performance are announced.
- CZI is expanding to include additional institutions outside of the Bay Area, with projects in Chicago and New York.

- The Huberman Lab Podcast features Andrew Huberman, a professor of neurobiology and ophthalmology at Stanford School of Medicine.
- The guests on the podcast are Mark Zuckerberg, CEO of Meta (including Facebook, Instagram, WhatsApp), and Dr. Priscilla Chan, co-founder of the Chan Zuckerberg Initiative (CZI).
- The CZI aims to cure all human diseases through funding, cell research, and AI platforms.
- The first hour of the discussion focuses on the CZI and the personal motivations of Chan and Zuckerberg.
- The second half of the discussion covers meta platforms, their impact on mental health, VR, augmented reality, mixed reality, and the potential of AI to transform everyday life.

- The podcast is separate from the speaker's teaching and research roles at Stanford.
- The speaker thanks the sponsors of the podcast, Eight Sleep and Element.
- Eight Sleep offers smart mattress covers with temperature control and sleep tracking features.
- Element is an electrolyte drink that provides essential nutrients for cell functioning.
- The speaker announces upcoming live events in Australia focused on mental health, physical health, and performance.

- The CZI Biohub is expanding to include additional institutions outside of the Bay Area.
- The Chicago Biohub is focused on building sensors to understand the body, while the New York Biohub is engineering cells to identify changes in the human body.
- The Chicago team is studying cells and tissue, starting with skin, to understand inflammation and other processes.
- The New York team is using engineered immune cells as microscopes to examine and potentially treat conditions like coronary artery health and neurodegenerative diseases.
- Both projects are ambitious and may take 10 to 15 years to complete.

- The decision to do the work of CZI within existing universities was motivated by the desire to leverage the structures and resources already present in academia.
- The Biohub teams are independent of the universities but partner with them to allow faculty to contribute to the overall project.
- CZI takes a long-term iterative approach, trying different models and doubling down on those that produce interesting results.
- CZI believes in collaboration but acknowledges that their approach is not the only way to do things.
- CZI is not directly involved in the implementation of new therapeutics, but they work with rare disease groups to fund research and incentivize drug developers.

- The speakers are both optimists, but their optimism manifests in different ways.
- One speaker is technologically optimistic about what can be built, while the other has a focus on improving people's lives.
- The speakers' relative optimism affects their time management, with one being late and the other being punctual.
- The CZI (Chan Zuckerberg Initiative) is driven by optimism and aims to make the future better by treating and eliminating diseases.
- Having children has influenced the speakers' view of the future and has given them a sense of urgency in their work.

- InsideTracker is a personalized nutrition platform that analyzes data from blood and DNA to help understand the body and reach health goals.
- Regular blood work is important for understanding factors that impact immediate and long-term health.
- InsideTracker provides personalized directives related to nutrition, behavioral modification, and supplements to help optimize levels of metabolic factors, lipids, hormones, etc.
- Listeners can get 20% off any InsideTracker plan by visiting insidetracker.com/Huberman.
- The discussion with Mark Zuckerberg will follow.

- The speaker is well-known for their role in technology development but is also becoming synonymous with health due to their personal interests and the intersection of technology with mental and physical health.
- The impact of technology on health is not all good or all bad, but rather depends on how it is used.
- Meaningful connections and friendships formed through technology can bring happiness and contribute to longer and healthier lives.
- Social media can have negative aspects such as bullying, but efforts are being made to ensure safety and provide parental controls.
- Passive consumption of online content, especially negative news, may have a more negative impact on well-being compared to connecting with others and learning enriching and inspiring content.

- The speaker acknowledges that negative experiences are undesirable and that certain content on Instagram can be like "highly processed food" that is engrossing but not nutritious.
- They mention being drawn to street fight videos on Instagram, even though they don't enjoy violence, and also enjoying cute animal content.
- The speaker questions whether the algorithm on Instagram is simply reflective of prior search behavior or if it is designed to provide a positive experience.
- They discuss how the algorithm has been adjusted to minimize clickbait and improve user experience based on feedback from real people.
- The speaker emphasizes the importance of not being paternalistic and allowing users to like what they want, except for content that is clearly harmful or violates community standards.

- The speaker had a positive experience learning about safety protections for kids on meta platforms.
- They realized that many people may not be aware of the existence of these tools.
- The speaker suggests that more information about these tools should be provided to users.
- They mention the importance of showing these tools in context within the product.
- Different tools with varying levels of power and nuance are needed to allow users to tailor their experience.

- There is no clear data on how much time on social media is too much, as it depends on various factors.
- There are tools available to help users manage their time on social media platforms.
- The speaker mentions the possibility of a self-lockout function to limit access to the app.
- The future of social media may involve augmented reality glasses and more immersive experiences.
- It is important to consider how social media is being used and its impact on mental state, but complete restriction is not necessary.

- The speaker is excited about the new VR platforms, specifically the Oculus and Ray-Ban glasses.
- They mention that the VR experience interfaces well with the real room and does not cause dizziness.
- The conversation shifts to discussing mixed reality, which combines virtual and augmented reality.
- The potential future of augmented reality is discussed, where holograms could replace physical objects.
- The speaker highlights the power of a headset that can do both virtual reality and augmented reality, allowing for new collaborative experiences.

- The speaker tried a VR exercise class that simulated boxing and found it engaging and effective in raising heart rate.
- They express a dislike for on-screen fitness activities like stationary biking or running on a treadmill.
- The speaker believes that incorporating physical activity into computing platforms is important and captures the essence of human experience.
- They discuss the potential for VR to transform traditional exercise routines and offer new ways to measure flexibility and form.
- The speaker acknowledges that there are still challenges in tracking and simulating certain movements, such as kicks and grappling, but is excited about the possibilities for future development.

- Priscilla and Mark launched the Chan Zuckerberg Initiative (CZI) in 2015 with the goal of building a better future for everyone.
- The big mission of CZI is to cure, prevent, or manage all diseases by the end of the century.
- CZI's strategy involves funding great scientists, building software tools to facilitate scientific work, and conducting their own scientific research.
- They have established Biohubs, collaborative institutes, to tackle grand challenges in scientific research.
- The ultimate aim is to make new discoveries and advancements in basic science to improve people's well-being.

- The use of virtual mediums for painting, art, and music can provide new opportunities for learning and expression.
- Virtual piano demos can teach users how to play songs by highlighting the keys they need to press.
- Virtual instruments like pianos can be more affordable and accessible, especially for those with limited income or space.
- The future may bring apps or hologram pianos that offer a more affordable alternative to physical pianos.
- The use of mixed reality and virtual solutions can have profound impacts on fields like surgery, education, and social interaction.

- The speaker tried on a pair of Ray-Ban glasses that allowed them to call out commands and listen to music with clarity.
- The glasses are designed to eventually become a stylish and comfortable augmented reality product.
- The glasses aim to provide a full vision of augmented reality, but there are technological challenges to overcome.
- There are two approaches to building the glasses: a long-term version and a current version with basic features like a camera and microphone.
- The glasses have the potential to incorporate AI and assist with various tasks, but there are concerns about privacy and consent.

- The company aims to build accessible products that can be used by everyone, rather than charging premium prices like Apple.
- The glasses they are developing could potentially solve the problem of myopia caused by excessive screen time, as spending time outdoors can reverse the condition.
- The glasses can measure and track the user's viewing habits and provide information about their visual system and attention.
- The glasses have external sensors to capture what the user sees, as well as eye tracking capabilities for interface control.
- There are design and technology trade-offs to consider, such as the thickness of the glasses and the inclusion of additional sensors, which may affect the price and functionality of the product.

- The speaker discusses the potential for AI interfaces and avatars of people on social media.
- They mention the desire for creators to have AI versions of themselves to answer questions and engage with their community.
- The speaker emphasizes the importance of controlling the AI version of oneself and ensuring it accurately represents them.
- They mention the idea of creating new AI personas that are not modeled after existing people, making it easier to ensure fidelity.
- The speaker expresses excitement about the positive impact AI can have on social engagement, learning, and mental and physical health.

- The podcast host asks listeners to support the podcast by subscribing to their YouTube channel, Spotify, and Apple podcasts, and leaving a five-star review.
- The host mentions sponsors and encourages listeners to check them out to support the podcast.
- The host invites listeners to leave questions and comments in the YouTube comment section.
- The host mentions that previous episodes of the podcast have discussed supplements and directs listeners to a website to learn more about them.
- The host provides information on how to follow them on social media and mentions that they discuss science-related topics on those platforms.

- The goal of CZI is to provide tools to accelerate scientific research and discovery.
- CZI believes that most large-scale discoveries are preceded by the invention of new tools or ways to observe things.
- CZI is focused on understanding how individual cells operate and is working on the Human Cell Atlas project.
- The next 10 years should be focused on being able to measure and observe more things in human biology.
- CZI wants to build tools for biology to understand how the human body works, with a focus on cells.

- CZI is focused on bringing unique interventions to the quest to cure all diseases.
- They recognize that money is necessary but not sufficient, and they also prioritize the ability to see and understand disease processes.
- CZI is involved in three main avenues: understanding disease processes and healthy processes, developing hardware such as microscopes and lenses, and managing data with the help of AI.
- They fund science, incentivize new points of view, collaboration, and open science through grants.
- CZI also builds software and hardware, collaborates with scientists to create durable and scalable tools, and has institutes focused on imaging work and grand challenges.

- Cells are the smallest unit of life in the body, with an estimated 37 trillion different cells.
- Understanding how mutations in DNA lead to sickness is a current focus in the field.
- The process of how mutations are translated and acted upon in cells is being studied.
- mRNA carries instructions from DNA, and cells interpret these instructions differently in healthy and sick states.
- The use of large language models and data sets can help gain insights and potentially create a virtual cell for faster learning and advancements in science and medicine.

- Single cell sequencing has revealed the existence of multiple types of fat cells, which may be important in understanding conditions like diabetes and obesity.
- Single cell sequencing is a hypothesis-generating experiment that can help identify genes that differ dramatically between cell types.
- AI can help in placing lists of genes into hypotheses for further testing.
- Single cell methodologies have led to the discovery of new cell types and have changed our understanding of diseases like cystic fibrosis.
- Tools like Cell by Gene allow researchers to identify which cell types express specific genes and can help generate hypotheses and inform drug development.

- Quality nutrition is important for physical and mental health, cognitive functioning, memory, learning, and focus.
- High quality nutrition includes vitamins, minerals, probiotics, prebiotics, and fiber from unprocessed or minimally processed sources.
- Getting enough servings of fruits, vegetables, fiber, and probiotics can be challenging for many people.
- AG1 is a product that provides foundational nutritional needs and can help ensure optimal mental and physical health and performance.
- There is a special offer available for AG1 at drinkag1.com/huberman.

- The speaker believes that there will continue to be new cell types discovered.
- They highlight the strengths of modern LLMs (Life Sciences AI clusters) in imagining different states of cells.
- The speaker mentions the Human Cell Atlas and the large corpus of data that can be used to train models.
- They acknowledge that modern LLMs have flaws, such as hallucinations, but can be valuable as hypothesis generators.
- The speaker praises CZI's ability to fund longer-term, larger projects that require significant resources and collaboration.

- Large language models (LLMs) are tools used in machine learning to find patterns in large amounts of data.
- The transformer model architecture, developed by Google, allows for the scaling of LLMs to process even more data.
- LLMs can be used for various applications, such as predicting news stories or generating chatbot responses.
- LLMs are not limited to processing human language and can be trained on other types of data, such as genetics or protein data.
- In silico experiments, conducted by machines, are becoming more prevalent in biomedical research, but caution is needed to ensure the results translate to humans.

Mark Zuckerberg & Dr. Priscilla Chan: Curing All Human Diseases & the Future of Health & Technology